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KMID : 0391520140220020072
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Journal of the Korean Child Neurology Society
2014 Volume.22 No. 2 p.72 ~ p.76
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The Effectiveness and Tolerability of Topiramate and Lidocaine Add-on Therapy in Children with Refractory Status Epilepticus
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Kang Bong-Hwa
Sohn Young-Soo
Kim Jung-Eun
Hwang Su-Kyeong
Kwon Soon-Hak
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Abstract
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Purpose: This study was aimed to compare the effectiveness and tolerability of topiramate add-on therapy versus lidocaine add-on therapy in children with refractory status epilepticus.
Methods: We performed a retrospective analysis of children with refractory status epilepticus who were hospitalized at Kyungpook National University Hospital during the period 2005 to 2012. We divided them into two groups, Group A (midazolam, MDZ, and Topiramate, TPM:11 patients) and Group B (midazolam and lidocaine, LDC:7 patients). Furthermore, they were sub-categorized according to children’s sex, age, seizure duration, and seizure type. To comepare the effectiveness and tolerability between the two groups, we evaluated seizure freedom, ＞50% seizure reduction, adverse events and mortality rates, respectively.
Results: In MDZ/TPM group, average dosage of midazolam infusion was 10.8±6.8 mcg/kg/min, seizure freedom was achieved in 1 out of 11 patients (9%) and ＞50% seizure reduction was in 2 out of 11 patients (18%). On the other hand, in MDC/ LDC group, average dosage of midazolam infusion is 11.3±5.2 mcg/kg/min, seizure freedom was achieved in 2 out of 7 patients (29%) and ＞50% seizure reduction was 3 out of 7 patients (43%). Aside from the promising effects, there was no significant difference between the two groups.
Conclusion: In children with refractory status epilepticus, topiramate or lidocaine add-on therapy seemed to be effective and fairly tolerated and showed no serious adverse effects. Therefore they can be an alternative treatment option. However, further studies are required.
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KEYWORD
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Refractory status epilepticus, Midazolam, Topiramate, Lidocaine, Children
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